Senior Staff Scientist - Ordovas-Montanes Lab

Company: Boston Children's Hospital
Location: Boston
Posted on: May 31, 2025

Job Description:

Position Summary/ Department Summary:
The Division of Gastroenterology is seeking a Senior Staff Research Scientist to join the (Boston Children's Hospital). This lab specializes in understanding the principles of how inflammation drives memory formation in barrier tissues with the goal of developing new therapeutic avenues for human disease. This individual will help to lead a collaborative project to understand mucosal immunity to respiratory infection and vaccination. The candidate will work under the direct supervision of Dr. Jose Ordovas-Montanes and be responsible for managing a small team of Research Assistants and Data Scientists.

This position offers an opportunity to develop leadership and management skills while working in an interdisciplinary environment with access to resources across Boston Children's Hospital and Harvard Medical School. This position is ideal for those individuals interested in advancing their careers in single-cell science with a focus on enabling, educating, and building leadership capacity.

Key Responsibilities:

• Direct and manage the execution of a large-scale integrated experimental and computational single-cell RNA-sequencing (scRNA-seq) based research project. Specific responsibilities will include:
  • Overall project management
  • Training individuals in experimental and computational scRNA-seq methods
  • Meeting timelines and specific deliverables
  • Regular reporting and communication within the lab and to external collaborators
  • Demonstrate a track record in scRNA-seq technologies, team management, and scientific publishing, preferably with a strong interest in immunology
  • May develop independent research projects and experiments of moderate to high complexity which includes maintenance of high quality documentation, analysis and proper interpretation of data, and preparation of reports, presentations, or other technical communications as necessary
  • Collaborates with Principal Investigator(s) in determining original scientific research projects' goals, methodologies and deliverables
  • May manage research lab personnel and oversee lab operations. May help train and supervise students and post-doctoral fellows. Participates in writing of grant proposals, planning and implementing technical meetings and symposia
    Minimum Qualifications
    Education:
    • A PhD in Biology, Systems Biology, Immunology, Chemistry, or similar field is requiredExperience:
      • A minimum of 4 years of original and relevant research experience is required
      • Experience as a Postdoctoral Fellow or relevant experience in the Biotechnology or Pharmaceutical sector is preferred but not required
      • Demonstrated expertise in both experimental and computational scRNA-seq approaches, including 10x Genomics
      • Experience with Next Generation Sequencing data analysis and alignment, especially via Cloud Computing and High-Performance Computing
      • Proficiency in data analysis in R and/or python; experience with pipelining in nextflow is preferred but not required
      • Strong mentorship track record with multiple mentees/direct reports
      • Knowledge in respiratory tract, epithelial cell, and/or viral infection biology
        Boston Children's Hospital offers competitive compensation and unmatched benefits including flexible schedules, affordable health, vision and dental insurance, child care and student loan subsidies, generous levels of time off, 403(b) Retirement Savings plan, Pension, Tuition and certain License and Certification Reimbursement, cell phone plan discounts and discounted rates on T-passes. Experience the benefits of passion and teamwork.
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Keywords: Boston Children's Hospital, Newton , Senior Staff Scientist - Ordovas-Montanes Lab, Healthcare , Boston, Massachusetts