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Research Associate, Upstream Process Development - Gene Therapy

Company: Homology Medicines
Location: Bedford
Posted on: August 23, 2019

Job Description:

Research Associate, Upstream Process Development - Gene Therapy Location: Bedford, MA Homology Medicines seeks an outstanding research associate in the Upstream Process Development team to assist in vector development and viral production processes. The individual in this role will be a highly-skilled, talented and motivated researcher who will focus on development of plasmids AAV manufacturing. We seek candidates with proven ability to work independently and collaboratively to achieve optimized project plans, with the goal to deliver products that transform the lives of patients. Homology Medicines seeks an outstanding research associate in the Upstream Process Development team to assist in vector development and viral production processes. The individual in this role will be a highly-skilled, talented and motivated researcher who will focus on development of plasmids AAV manufacturing. We seek candidates with proven ability to work independently and collaboratively to achieve optimized project plans, with the goal to deliver products that transform the lives of patients. Primary responsibilities:

  • Carry out routine production of AAV vectors in adherent and suspension platform
  • Characterize scale-up processes for AAV production focusing on a bioreactor scale up approaches using both adherent and suspension cells
  • Assist in routine cloning and characterization of plasmids used in vector production
  • Performance of a variety of molecular biology assays including SDS-PAGE, PCR, nucleotide sequencing, and recombinant plasmid cloning and generation
  • Coordinating with external vendors for plasmid analysis and scaled up production
  • Maintain appropriate production protocols and analytical results in company databases and electronic lab notebooks
  • Author technical reports as needed
    Education & Experience
    • BS or equivalent with 2+ years industry experience or MS in relevant field
    • Experience with mammalian cell culture in both adherent and suspension formats
    • Experience in molecular techniques including plasmid cloning, restriction digest, sequencing, and transient transfection
    • Background in AAV cloning or production is strongly desired, virus or protein production experience in required
    • Adept at conducting routine testing and limited troubleshooting of multiple methods.
    • Independently motivated, detail oriented and good problem solving ability.
    • Excellent interpersonal written and oral communication skills. Homology Medicines, Inc. (HMI) has built foundational intellectual property on gene editing and gene therapy vectors derived from naturally occurring human adeno-associated viruses (AAVs). The Company's technology is precise, on-target and highly efficient for in vivo editing of genetic mutations. This transformative platform technology, combined with an elite leadership team of biopharmaceutical industry veterans, create a significant opportunity for HMI to rapidly advance a diverse pipeline of new medicines that address and potentially cure the underlying cause of genetic diseases.

Keywords: Homology Medicines, Newton , Research Associate, Upstream Process Development - Gene Therapy, Healthcare , Bedford, Massachusetts

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