Senior Scientist, Materials Science
Posted on: June 8, 2021
The Senior Scientist - Materials Science position is a
laboratory-based position with responsibility for investigating and
understanding the solid state chemistry of Pfizer's drug molecules.
Responsibilities include generating solid state chemistry data
using state-of-the-art instrumentation and computer models, and
interpreting the data to allow new medicines to be brought to the
market. This role serves on multidisciplinary project teams and is
responsible for defining the final drug substance form
(salt/polymorph/hydrate) of active pharmaceutical ingredients (API)
and the preferred physical attributes (particle shape/particle
size/surface energy) needed for optimum API and drug product
performance. The position is based in Groton, CT (USA).
- Conduct solid state physical and chemical characterization of
small molecules of pharmaceutical relevance. This includes particle
characterization (e.g., particle size, shape) and solid state
characterization (e.g., spectroscopy, X-ray powder diffraction,
- Crystallize neutral molecules, salt and co-crystal forms of
drug candidates (including hydrates, solvates and polymorphs) and
evaluate these forms for acceptability as drug substances as it
relates to chemical manufacturing and formulation into
- Apply state-of-the-art computational approaches to predict the
properties and performance of crystalline and amorphous drug
- Oversee the work of external partners conducting laboratory
studies, and provide tactical guidance and critical analysis of raw
- Solve scientific problems using contemporary solid state
experimental and computational techniques.
- Participate on multidisciplinary project teams, and collaborate
with colleagues to define and implement screening and
characterization strategies according to project timelines.
- Draft and review sections of regulatory submissions as well as
delivering reports to support patenting Pfizer's intellectual
- Provide materials science support for colleagues in other
- Lead the development of new scientific approaches and knowledge
within the global Materials Science organization.
- A PhD in chemistry, engineering, materials science, or
pharmaceutics (or equivalent subject) and 0-4 years of relevant
experience is required, or a MS in chemistry, engineering,
materials science, or pharmaceutics (or equivalent subject) and 5+
years of relevant experience is needed.
- The candidate should have experience in small molecule
crystallization and solid state characterization (such as x-ray
powder diffraction, polarized light microscopy, differential
scanning calorimetry, thermogravimetric analysis, NMR, etc).
- Strong data analysis skills and knowledge of statistical
concepts are also needed.
- A strong interest and motivation to learn new technologies and
concepts is expected.
- Good organizational skills, the ability to work independently,
and excellent oral and written communication skills are
- Experience with using contemporary computational approaches to
predict the properties and performance of pharmaceutical materials
- Understanding of the physical properties needed for drug
substance manufacture and formulation into drug product is
No special physical/mental requirements are needed for this
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT
No special non-standard work schedule, travel or environmental
requirements exist for this position.
OTHER JOB DETAILS
Pfizer reports payments and other transfers of value to health
care providers as required by federal and state transparency laws
and implementing regulations. These laws and regulations require
Pfizer to provide government agencies with information such as a
health care provider's name, address and the type of payments or
other value received, generally for public disclosure. Subject to
further legal review and statutory or regulatory clarification,
which Pfizer intends to pursue, reimbursement of recruiting
expenses for licensed physicians may constitute a reportable
transfer of value under the federal transparency law commonly known
as the Sunshine Act. Therefore, if you are a licensed physician who
incurs recruiting expenses as a result of interviewing with Pfizer
that we pay or reimburse, your name, address and the amount of
payments made currently will be reported to the government. If you
have questions regarding this matter, please do not hesitate to
contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and
conditions of employment for all employees and job applicants
without regard to race, color, religion, sex, sexual orientation,
age, gender identity or gender expression, national origin,
disability or veteran status. Pfizer also complies with all
applicable national, state and local laws governing
nondiscrimination in employment as well as work authorization and
employment eligibility verification requirements of the Immigration
and Nationality Act and IRCA. Pfizer is an E-Verify employer.
Research and Development
Keywords: Pfizer, Newton , Senior Scientist, Materials Science, Other , Groton, Massachusetts
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